Órgano oficial de Instituto Panvascular de Occidente, S.C.
Reacción Sarcoidosis-like en Paciente a Tratamiento con Pembrolizumab en Adenocarcinoma de Pulmón Enfermedad Avanzada
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Palabras clave

Sarcoidosis
Inmunoterapia
Diagnóstico diferencial

Categorías

Cómo citar

1.
Reacción Sarcoidosis-like en Paciente a Tratamiento con Pembrolizumab en Adenocarcinoma de Pulmón Enfermedad Avanzada. Rev Med Clin [Internet]. 2026 Jan. 6 [cited 2026 Jan. 8];10(1):e06012610004. Available from: https://medicinaclinica.org/index.php/rmc/article/view/718

Resumen

La sarcoidosis es una toxicidad poco frecuente de la inmunoterapia. Es necesario prestar atención a las diferentes manifestaciones para iniciar el tratamiento a tiempo y evitar confundirla con la progresión tumoral. Normalmente se controla bien con tratamiento corticoideo, valorando en cada caso si mantener o no la inmunoterapia. Se lleva a cabo una revisión del estado del arte, ilustrando un caso clínico. 

PDF Reporte de Caso

Referencias

Karl W. Thomas, MD, Gary W. Hunninghake, MD. Sarcoidosis. JAMA, June 25 2003- Vol. 289 , No. 24.

Pascal Sève, Yves Pacheco, François Durupt, Yvan Jamilloux, Mathieu Gerfaud-Valentin, Sylvie Isaac, Loïc Boussel, Alain Calender, Géraldine Androdias, Dominique Valeyre and Thomas El Jammal. Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis. Cells 2021, 10, 766. https://doi.org/10.3390/cells10040766

Mariam Charkviani and Sandra M. Herrmann. Immune Checkpoint Inhibitor–Associated sarcoidosis Reaction in the Kidney: Case Report. Kidney Med. 2023 May; 5(5): 100626. Published online 2023 Mar 13. doi: 10.1016/j.xkme.2023.100626

Noémie Chanson, Manuel Ramos-Casals, Xerxes Pundole. Immune checkpoint inhibitor-associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation. Eur J Cancer. 2021 Nov:158:208-216. doi: 10.1016/j.ejca.2021.05.041. Epub 2021 Aug 25.

Y Li, R R Flavell, R Juarez, M Chow, C Wu, K Tsai, A Daud, S C Behr. Retrospective study of the incidence of sarcoidosis-like reaction in patients treated with immunotherapy. Clin Radiol, 2023 Feb;78(2):e131-e136. doi: 10.1016/j.crad.2022.09.127. Epub 2022 Nov 4.

C Torrecilla-Vall-Llossera, A Jucglà Serra, J Molinero Caturla, C Moreno-Vílchez, R M Penín Mosquera, J Marcoval Caus. Sarcoid-like Reactions to Immune Checkpoint Inhibitors. Actas Dermosifiliogr. 2024 DOI: 10.1016/j.ad.2023.03.010

Haoqian Li, Fengchun Mu, Bing Zou, Linlin Wang. Pulmonary sarcoidosis-like reactions induced by sintilimab in esophageal cancer: A case report. Medicine (Baltimore). 2023 Aug 4;102(31):e34432. doi: 10.1097/MD.0000000000034432. DOI: 10.1097/MD.0000000000034432

Alberto Torres-Zurita, Lucía Vázquez-Montero, Laura Gallego-López, María Dolores Mediano-Rambla, and Luis de la Cruz-Merino. Sarcoidosis-like reaction induced by immune checkpoint inhibitor in a patient with hepatocellular carcinoma: a case report. Front Immunol. 2023; 14: 1150128. Published online 2023 Sep 13. doi: 10.3389/fimmu.2023.1150128

Ignacio Gayá García-Manso, María Del Mar García Ródenas, María Encarnación Barroso Medel, Francisco José Illán Gambín. Sarcoidosis-Like Granulomatous Reaction Associated With Pembrolizumab Immunotherapy. Arch. Bronconeumol (Engl Ed) 2018 Nov;54(11):592-593. doi: 10.1016/j.arbres.2018.04.010. Epub 2018 May 22.

Oadi N. Shrateh, Yazan Abugharbieh, Yousef Abu Asbeh, Hani Hour, Iyad Awad, and Sami Bannoura. Sarcoid-like reaction and hypothyroidism induced by PD-1 inhibitor treatment in metastatic renal cell carcinoma: A case report and literature review. BMC Pulm Med. 2024; 24: 123. Published online 2024 Mar 8. doi: 10.1186/s12890-024-02943-9.

Mathew R. Birnbaum, BS, Michelle W. Ma, MD, Sarah Fleisig, MD, Stuart Packer, MD, Bijal D. Amin, MD, Mark Jacobson, MD, and Beth N. McLellan. Nivolumab-related cutaneous sarcoidosis in a patient with lung adenocarcinoma. JAAD Case Rep. 2017 May; 3(3): 208–211. Published online 2017 Apr 14. doi: 10.1016/j.jdcr.2017.02.015.

Audrey Melin, Émilie Routier, Séverine Roy, Pauline Pradere, Jerome Le Pavec, Thibaut Pierre, Noémie Chanson, Jean-Yves Scoazec, Olivier Lambotte, and Caroline Robert. Sarcoid-like Granulomatosis Associated with Immune Checkpoint Inhibitors in Melanoma. Cancers (Basel). 2022 Jun; 14(12): 2937. Published online 2022 Jun 14. doi: 10.3390/cancers14122937

Anna J Lomax, Helen M McGuire, Catriona McNeil, Clara J Choi, Peter Hersey, Deme Karikios, Kerwin Shannon, Sebastian van Hal, Urszula Carr, Anne Crotty, Sandeep K Gupta, Jane Hollingsworth, Haewon Kim, Barbara Fazekas de St Groth, Neil McGill. Immunotherapy-induced sarcoidosis in patients with melanoma treated with PD-1 checkpoint inhibitors: Case series and immunophenotypic análisis. DOI: 10.1111/1756-185X.13076.

Christine M. Cornejo, Paul Haun, Joseph English III, Misha Rosenbach. Inmune chekpoint inhibitors and the development of granulomatous reactions. Review. Volume 81, issue 5, p1165-1175, november 2019. Doi.org/10.1016/j.jaad.2018.07.051.

Akiyoshi Katagiri, Hiroyuki Yamazaki, and Taro Ikeda. A case of sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic renal cell carcinoma. IJU Case Rep. 2022 Jan; 5(1): 15–18. Published online 2021 Sep 24. doi: 10.1002/iju5.12372

Terufumi Kubo, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Tadashi Hasegawa, and Toshihiko Torigoe. Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy. Hum Vaccin Immunother. 2021; 17(7): 1940–1942. Published online 2021 Feb 11.

Leonardo Chaves Machado, Eduardo Kaiser Ururahy Nunes Fonseca, Genival Viana de Oliveira Júnior, Gustavo Schvartsman, Rodrigo Caruso Chate. Sarcoid-like reaction induced by neoadjuvant immunotherapy in Stage III non-small cell lung cancer. 2024 Mar 29:22:eAI0810. doi: 10.31744/einstein_journal/2024AI0810. eCollection 2024.

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Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Derechos de autor 2026 Jorge del Río Fernández, Adán Rodríguez González, Elías Alejandro Alberrán Coria, Verónica Velasco Durántez, Claudia Alvargonzález Fernández, Esmeralda Mateo Álvarez, Lucía Palacio Aller

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