Síndrome de Trousseau como Causa de Infarto Cerebral en Joven
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Palabras clave

Infaro cerebral
Adenocarcinoma de Ovario
Síndrome de Trousseau

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Síndrome de Trousseau como Causa de Infarto Cerebral en Joven. (2020). Ictus, 1(1), e30092001006. https://doi.org/10.5281/zenodo.4075407

Resumen

El síndrome de Trousseau se caracteriza por la presencia de eventos trombóticos venosos o arteriales asociados a un paciente con cáncer visceral. Presentamos el caso de una mujer de 43 años sin antecedentes que presentó cuadro clínico de embolismos sistémicos con fiebre y que desarrolló infartos cerebrales múltiples de características embólicas. El cuadro progresivo y de eventos múltiples con fiebre y uso múltiple de antibióticos hizo sospechar como primera posibilidad endocarditis bacteriana. Se ingresó a hospital por recurrencia de infarto cerebral a pesar de tratamiento con aspirina para diagnóstico y tratamiento. Se confirmó la presencia de endocarditis no bacteriana asociada a carcinoma de ovario, haciéndose el diagnóstico de Síndrome de Trousseau. La evolución hospitalaria de la paciente fue tórpida presentándose hemorragia cerebral asociada a anticoagulantes, complicaciones sistémicas, y finalmente defunción de la paciente a los 61 días de iniciado el cuadro clínico.

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Referencias

Adams HP, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993;24(1):35-41. doi:10.1161/01.STR.24.1.35

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New Approach to Stroke Subtyping: The A-S-C-O (Phenotypic) Classification of Stroke. Cerebrovasc Dis. 2009;27(5):502-508. doi:10.1159/000210433

Smajlovic D. Strokes in young adults: epidemiology and prevention. Vasc Health Risk Manag. February 2015:157. doi:10.2147/VHRM.S53203

Nedeltchev K. Ischaemic stroke in young adults: predictors of outcome and recurrence. J Neurol Neurosurg Psychiatry. 2005;76(2):191-195. doi:10.1136/jnnp.2004.040543

GRAUS F, ROGERS LR, POSNER JB. Cerebrovascular Complications in Patients with Cancer. Medicine (Baltimore). 1985;64(1):16-35. doi:10.1097/00005792-198501000-00002

Dardiotis E, Aloizou A-M, Markoula S, et al. Cancer-associated stroke: Pathophysiology, detection and management (Review). Int J Oncol. January 2019. doi:10.3892/ijo.2019.4669

Cestari DM, Weine DM, Panageas KS, Segal AZ, DeAngelis LM. Stroke in patients with cancer: Incidence and etiology. Neurology. 2004;62(11):2025-2030. doi:10.1212/01.WNL.0000129912.56486.2B

Selvik HA, Thomassen L, Logallo N, Naess H. Prior Cancer in Patients with Ischemic Stroke: The Bergen NORSTROKE Study. J Stroke Cerebrovasc Dis. 2014;23(5):919-925. doi:10.1016/j.jstrokecerebrovasdis.2013.07.041

Selvik HA, Thomassen L, Bjerkreim AT, Naess H. Cancer-Associated Stroke: The Bergen NORSTROKE Study. Cerebrovasc Dis Extra. 2015;5(3):107-113. doi:10.1159/000440730

Sanossian N, Djabiras C, Mack WJ, Ovbiagele B. Trends in Cancer Diagnoses among Inpatients Hospitalized with Stroke. J Stroke Cerebrovasc Dis. 2013;22(7):1146-1150. doi:10.1016/j.jstrokecerebrovasdis.2012.11.016

Stefan O, Vera N, Otto B, Heinz L, Wolfgang G. Stroke in cancer patients: a risk factor analysis. J Neurooncol. 2009;94(2):221-226. doi:10.1007/s11060-009-9818-3

Navi BB, Reiner AS, Kamel H, et al. Association between incident cancer and subsequent stroke. Ann Neurol. 2015;77(2):291-300. doi:10.1002/ana.24325

Blom JW. Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis. JAMA. 2005;293(6):715. doi:10.1001/jama.293.6.715

Navi BB, Reiner AS, Kamel H, et al. Risk of Arterial Thromboembolism in Patients With Cancer. J Am Coll Cardiol. 2017;70(8):926-938. doi:10.1016/j.jacc.2017.06.047

Varki A. Trousseau’s syndrome: multiple definitions and multiple mechanisms. Blood. 2007;110(6):1723-1729. doi:10.1182/blood-2006-10-053736

De Stefano V. Arterial thrombosis and cancer: the neglected side of the coin of Trousseau syndrome. Haematologica. 2018;103(9):1419-1421. doi:10.3324/haematol.2018.197814

Sack GH, Levin J, Bell WR. Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore). 1977;56(1):1-37. http://www.ncbi.nlm.nih.gov/pubmed/834136.

Hasegawa Y, Setoguchi T, Sakaida T, Iuchi T. Utility of a scoring system for differentiating cancer-associated stroke from cryptogenic stroke in patients with cancer. Neurol Sci. 2020;41(5):1245-1250. doi:10.1007/s10072-019-04231-5

Karlińska AG, Gromadzka G, Karliński MA, Członkowska A. The Activity of Malignancy May Determine Stroke Pattern in Cancer Patients. J Stroke Cerebrovasc Dis. 2015;24(4):778-783. doi:10.1016/j.jstrokecerebrovasdis.2014.11.003

Dearborn J, Urrutia V, Zeiler S. Stroke and Cancer- A Complicated Relationship. J Neurol Transl Neurosc. 2014;2(1):1039.

Borowski A, Ghodsizad A, Gams E. Stroke as a first manifestation of ovarian cancer. J Neurooncol. 2005;71(3):267-269. doi:10.1007/s11060-004-1394-y

Potugari BR, Priyanka P, Komanapalli SD, Mercier RJ. Ovarian Cancer Presenting as Cryptogenic Stroke from Patent Foramen Ovale. Clin Med Res. 2019;17(3-4):97-101. doi:10.3121/cmr.2019.1444

Kunitake K, Inagaki R, Furukawa S, Kitagawa S, Oguchi H, Ito Y. Alternating Amaurosis Fugax in Trousseau Syndrome: A Case Report. J Stroke Cerebrovasc Dis. 2019;28(7):e92-e94. doi:10.1016/j.jstrokecerebrovasdis.2019.04.018

Winter WE, Seidman J, Krivak TC, Pujari SG, Boice CR, Carlson JW. Papillary Serous Adenocarcinoma of the Ovary Diagnosed after Malignant Pericardial Tamponade and Embolic Stroke. Gynecol Oncol. 2002;84(3):453-455. doi:10.1006/gyno.2001.6505

Kanthasamy V, Natarajan I. Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. JRSM Open. 2016;7(11):205427041666930. doi:10.1177/2054270416669304

Lin Y-K, Lee J-T, Yang F-C, et al. Systemic embolic events with nonbacterial thrombotic endocarditis as manifestations of recurrent ovarian clear cell carcinoma. Taiwan J Obstet Gynecol. 2015;54(5):625-628. doi:10.1016/j.tjog.2015.08.021

Devulapalli S, Pinto N, Gandothra C, Jayam-Trouth A, Kurukumbi M. A Rare Case of Occipital Stroke as a Consequence of Nonbacterial Thrombotic Endocarditis in Ovarian Clear Cell Carcinoma: A Case Report. Case Rep Neurol. 2012;4(1):84-91. doi:10.1159/000338811

Takano H, Nakajima K, Nagayoshi Y, et al. Clinical associations of Trousseau’s syndrome associated with cerebral infarction and ovarian cancer. J Gynecol Oncol. 2018;29(5). doi:10.3802/jgo.2018.29.e67

Kuan A-S, Teng C-J, Wu H-H, et al. Risk of ischemic stroke in patients with ovarian cancer: a nationwide population-based study. BMC Med. 2014;12(1):53. doi:10.1186/1741-7015-12-53

Nouh AM, Staff I, Finelli PF. Three Territory Sign. Neurol Clin Pract. 2019;9(2):124-128. doi:10.1212/CPJ.0000000000000603

Umemura T, Yamamoto J, Akiba D, Nishizawa S. Bilateral cerebral embolism as a characteristic feature of patients with Trousseau syndrome. J Clin Neurosci. 2017;42:155-159. doi:10.1016/j.jocn.2017.04.014

Chen W, He Y, Su Y. Multifocal cerebral infarction as the first manifestation of occult malignancy: Case series of trousseau’s syndrome and literature review. Brain Circ. 2018;4(2):65. doi:10.4103/bc.bc_1_18

Kuroda N, Hiramatsu H, Mori M, Tanaka T. Mechanical Thrombectomy for Trousseau Syndrome in a Terminally Ill Cancer Patient. J Pain Symptom Manage. 2019;57(3):688-694. doi:10.1016/j.jpainsymman.2018.12.327

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