Keywords
Sepsis
Critical Illness
Biomedical Research
Bibliometrics
Categories
How to Cite
Abstract
Introduction: Drug resistance is a priority in public health and global health. In critically ill patients, drug resistance is a strong predictor of high mortality. To date, scientific development and patterns of global research on drug resistance in sepsis in critically ill patients are unknown. Methods: A bibliometric study using Scopus as a data source. The R package bibliometrix was used to visualize the results. Results: 3323 articles were included, published between 1972 and 2024. Among these, 79% (n= 2524) correspond to articles with primary data, followed by reviews with 15% (n= 523). International collaboration was 16.82%, and annual scientific growth was 7.73%. Clinical research, cross-infection, bacteremia, antibacterial agents, and middle-aged are the most used keywords. In the last 5 years, cross-infection, bacteremia, and the elderly have been the most popular topics. The United States has the largest collaboration network. Apart from Mexico and Brazil, no other Latin American country was identified as standing out in international collaboration. Conclusions: A gradual growth in scientific development of drug resistance in sepsis was evidenced, with a notable rise in recent years, focusing essentially on clinical research testing antimicrobial agents in the middle-aged and elderly population. In Latin America, participation in collaborations was very low compared to other continents. These data can be used for the analysis and interpretation of patterns and research gaps.
References
Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022; 399(10325):629-655. doi: 10.1016/S0140-6736(21)02724-0
Antimicrobial Resistance Collaborators. The burden of antimicrobial resistance in the Americas in 2019: a cross-country systematic analysis. Lancet Reg Health Am. 2023; 25:100561. doi: 10.1016/j.lana.2023.100561
Pradipta IS, Sodik DC, Lestari K, Parwati I, Halimah E, Diantini A, et al. Antibiotic resistance in sepsis patients: evaluation and recommendation of antibiotic use. N Am J Med Sci. 2013; 5(6):344-52. doi: 10.4103/1947-2714.114165
Kumar NR, Balraj TA, Kempegowda SN, Prashant A. Multidrug-Resistant Sepsis: A Critical Healthcare Challenge. Antibiotics (Basel). 2024; 13(1):46. doi: 10.3390/antibiotics13010046
Legese MH, Asrat D, Swedberg G, Hasan B, Mekasha A, Getahun T, et al. Sepsis: emerging pathogens and antimicrobial resistance in Ethiopian referral hospitals. Antimicrob Resist Infect Control. 2022; 11(1):83. doi: 10.1186/s13756-022-01122-x
World Health Organization. WHO calls for global action on sepsis - cause of 1 in 5 deaths worldwide [Internet]. [Consultado 2 May 2024]. Disponible en: https://www.who.int/news/item/08-09-2020-who-calls-for-global-action-on-sepsis---cause-of-1-in-5-deaths-worldwide
Lozada-Martinez ID, Lozada-Martinez LM, Cabarcas-Martinez A, Ruiz-Gutierrez FK, Aristizabal Vanegas JG, Amorocho Lozada KJ, et al. Historical evolution of cancer genomics research in Latin America: a comprehensive visual and bibliometric analysis until 2023. Front Genet. 2024; 15:1327243. doi: 10.3389/fgene.2024.1327243.
Lozada-Martinez ID, Visconti-Lopez FJ, Marrugo-Ortiz AC, Ealo-Cardona CI, Camacho-Pérez D, Picón-Jaimes YA. Research and Publication Trends in Pediatric Surgery in Latin America: A Bibliometric and Visual Analysis from 2012 to 2021. J Pediatr Surg. 2023; 58(10):2012-2019. doi: 10.1016/j.jpedsurg.2023.04.003
Aria M, Cuccurullo C. Bibliometrix: An R-Tool for Comprehensive Science Mapping Analysis. J Informetr. 2017;11(4):959-975. doi: 10.1016/j.joi.2017.08.007
Yao H, Liu S, Zhang Z, Xiao Z, Li D, Yi Z, et al. A bibliometric analysis of sepsis-induced myocardial dysfunction from 2002 to 2022. Front Cardiovasc Med. 2023; 10:1076093. doi: 10.3389/fcvm.2023.1076093.
Cao Z, Zhang Y, Luo JH, Liao WQ, Cheng X, Zhan JH. A bibliometric analysis of publications on burn sepsis using VOSviewer. Front Med (Lausanne). 2022; 9:971393. doi: 10.3389/fmed.2022.971393
Akdagli Ekici A, Kisa A, Önder Turhan S. The evolution of sepsis publications and global productivity: A bibliometric analysis between 1980 and 2020. Medicine (Baltimore). 2024; 103(12):e37380. doi: 10.1097/MD.0000000000037380
Sun G, Zhang Q, Dong Z, Dong D, Fang H, Wang C, et al. Antibiotic resistant bacteria: A bibliometric review of literature. Front Public Health. 2022; 10:1002015. doi: 10.3389/fpubh.2022.1002015
Ablakimova N, Smagulova GA, Rachina S, Mussina AZ, Zare A, Mussin NM, et al. Bibliometric Analysis of Global Research Output on Antimicrobial Resistance among Pneumonia Pathogens (2013-2023). Antibiotics (Basel). 2023; 12(9):1411. doi: 10.3390/antibiotics12091411
Lozada-Martinez ID, Lozada-Martinez LM, Fiorillo-Moreno O. Leiden manifesto and evidence-based research: Are the appropriate standards being used for the correct evaluation of pluralism, gaps and relevance in medical research? J R Coll Physicians Edinb. 2024; 54(1):4-6. doi: 10.1177/14782715241227991.
Lozada-Martinez ID, Bolaño-Romero MP, Picón-Jaimes YA, Moscote-Salazar LR, Narvaez-Rojas AR. Quality or quantity? Questions on the growth of global scientific production. Int J Surg. 2022; 105:106862. doi: 10.1016/j.ijsu.2022.106862
Jensen EA, Reed M, Jensen AM, Gerber A. Evidence-based research impact praxis: Integrating scholarship and practice to ensure research benefits society. Open Res Eur. 2023; 1:137. doi: 10.12688/openreseurope.14205.2
Robinson KA, Brunnhuber K, Ciliska D, Juhl CB, Christensen R, Lund H, et al. Evidence-Based Research Series-Paper 1: What Evidence-Based Research is and why is it important? J Clin Epidemiol. 2021; 129:151-157. doi: 10.1016/j.jclinepi.2020.07.020
Lozada-Martinez ID, Ealo-Cardona CI, Marrugo-Ortiz AC, Picón-Jaimes YA, Cabrera-Vargas LF, Narvaez-Rojas AR. Meta-research studies in surgery: a field that should be encouraged to assess and improve the quality of surgical evidence. Int J Surg. 2023; 109(6):1823-1824. doi: 10.1097/JS9.0000000000000422
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright (c) 2024 Patrick Junior Brett-Cano, David Fernando Pupiales-Figueroa, Karol Silvana Quintero-Molano, Leidy Vanessa Rodriguez-Moreano, Kevin Andrés Orozco-Acuña, Dilberth David Benítez-Jiménez, María Alejandra Castañeda-Mejía , Guillermo Andrés Osma-Vargas , María Mónica Rangel-Gutiérrez , Cristian Camilo Blanco-Duarte , Michael Ortega-Sierra